Isoket IV Dosage/Direction for Use

Intravenous: Adult: A dose of between 2 mg and 12 mg per hour is usually satisfactory. However, dosages up to 20 mg/hr administered should be adjusted to the patient response.
Intracoronary: The usual dose is 1 mg given as a bolus injection prior to balloon inflation. Further doses may be given not exceeding 5 mg within a 30 minute period.
Children: The safety and efficacy of Isosorbide Dinitrate (Isoket) solution for I.V. infusion has not yet been established in children.
Elderly: No dose adjustment is necessary.
Renal and Hepatic Impairment: Isosorbide Dinitrate (Isoket) should be used with caution in patients with severely impaired renal or hepatic function (see Precautions).
Administration: Isoket is a concentrated solution and must be diluted prior use. The diluted solution should never be injected in the form of a bolus except via the intracoronary route prior to balloon inflation. A dilution of 50% is advocated for intracoronary administration.
Isosorbide Dinitrate (Isoket) solution for infusion can be administered as an intravenous admixture with a suitable vehicle (see Use and Handling under Cautions for Usage).
Prepared Isoket admixtures should be given by intravenous infusion or with the aid of a syringe pump incorporating a glass or rigid plastic syringe. During administration the patient's blood pressure and pulse should be closely monitored.
For IV or intracoronary use.